Tuesday, March 2, 2021
Literary Reviews
  • Home
  • OUR BOOK SHOP
    • Erotic Novels
    • BEST SELLING BOOKS
    • Science Fiction Books
    • Business and Management
    • Computing and IT
    • Cooking
    • Education
    • Religion & Spirituality
    • Self Help
    • Teens & Young Adults
  • Literary Review
  • Literature
  • Book Writing
  • Kindle Publishing
  • Romantic
  • Science Fiction
  • Cooking
  • MORE
    • Erotic
    • Mysteries, Thrillers
    • Literary Themes
    • Business and Management
    • Literary Agents
    • Literary Devices
    • New Books
    • Self Help
    • Teens & Young Adults Novels
    • Computing and IT
    • Education
    • Religion & Spirituality Novels
No Result
View All Result
Literary Reviews
Home Self Help

Pimavanserin Associated with Significant Improvement in Anxious Depression

admin by admin
October 26, 2020
in Self Help
0
Pimavanserin Associated with Significant Improvement in Anxious Depression
0
SHARES
1
VIEWS
Share on FacebookShare on Twitter

Related posts

Can hearing loss trigger depression?- The New Indian Express

Can hearing loss trigger depression?- The New Indian Express

March 2, 2021
4 steps to calmer you: Anxiety can be debilitating, but you can manage it with some training

4 steps to calmer you: Anxiety can be debilitating, but you can manage it with some training

March 1, 2021


Adjunctive pimavanserin was associated with a significant improvement in anxious depression in patients with major depression who didn’t respond to previous therapy, according to a secondary analysis of the CLARITY study published in the International Clinical Psychopharmacology journal.

Pimavanserin is a potential 5-hydroxytryptamine2A (5-HT2A) receptor antagonist/inverse agonist approved in the United States for treating hallucinations and delusions in patients with Parkinson disease psychosis. The researchers conducted a post-hoc analysis to evaluate the drug’s effects on anxious depression.

The researchers evaluated data from the CLARITY study, a randomized, double-blind, placebo-controlled study in patients with major depression and an inadequate response to previous therapy.

In the post-hoc analysis, pimavanserin produced a significantly greater effect on the HAMD-17 anxiety/somatization factor score vs. placebo in stage 1 (P = .0003) and across stages 1 and 2 using prespecified weighting (P = 0.0166), but not in stage 2 (P = .980). At week 5 in stage 1, the LS mean (SE) difference between placebo and pimavanserin for the anxiety/somatization factor score was −1.5 (0.41) (95% CI −2.4 to −0.7; P = .0003; Cohen’s d effect size: 0.634).

Anxiety was reported as an adverse event in stage 1 of the CLARITY study in two patients (1.3%).

Limitations include the fact that the study’s post-hoc design was not specified in the original analyses. The researchers also worked with a small sample size, and patients with comorbid anxiety were not prospectively identified.

“Ongoing phase 3 studies, with adjunctive pimavanserin in patients with major depressive disorder, will provide a larger population of patients in which the occurrence of anxious depression and the response to pimavanserin can be examined further,” the researchers concluded.

Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors’ disclosures.

Reference

Papakostas GI, Fava M, Freeman MP, Shelton RC, Thase ME, Jha MK, et al. Effect of pimavanserin on anxious depression in patients with major depression and an inadequate response to previous therapy: secondary analysis of the clarity study. Int Clin Psychopharmacol. 2020 Nov;35(6):313-321.

Tags: anxiousDepressionImprovementPimavanserinSignificant
Previous Post

Sheikh Zayed Book Award records highest number of submissions

Next Post

Faith Erin Hicks Talks Her New Graphic Novel Ride On, Horses, Star Trek, and More

Next Post
Faith Erin Hicks Talks Her New Graphic Novel Ride On, Horses, Star Trek, and More

Faith Erin Hicks Talks Her New Graphic Novel Ride On, Horses, Star Trek, and More

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

RECOMMENDED NEWS

IT News Online – Fujitsu Commences Joint Research with World-Leading Institutions for Innovations in Quantum Computing

IT News Online – Fujitsu Commences Joint Research with World-Leading Institutions for Innovations in Quantum Computing

5 months ago
The Literature of Love | Varsity

The Literature of Love | Varsity

3 weeks ago
Cambridge Quantum Computing Welcomes Dr. Stefano Pironio as Scientific Advisor for Quantum Cryptography

Cambridge Quantum Computing Welcomes Dr. Stefano Pironio as Scientific Advisor for Quantum Cryptography

3 weeks ago
‘Solid Ground’ by T.W. Lewis Garners Literary Titan Gold Award

‘Solid Ground’ by T.W. Lewis Garners Literary Titan Gold Award

2 weeks ago

Products

  • Teen Titans GO! Box Set (Cover Image may vary) £22.34
  • Sacrifice of Love, (Book 7 The Grey Wolves) (The Grey Wolves Series) £3.92
  • The Spy and the Traitor: The Greatest Espionage Story of the Cold War £7.49
  • When Evil Comes To Play (The Veil Diaries Book 5) £3.56
  • American King (3) (New Camelot) £13.00

BROWSE BY CATEGORIES

  • Book Writing
  • Business and Management
  • Computing and IT
  • Cooking Books
  • Education
  • Erotic
  • Kindle Publishing
  • Literary Agents
  • Literary Devices
  • Literary Review
  • Literary Themes
  • Literature
  • Mysteries, Thrillers & Suspense
  • New Books
  • Religion & Spirituality
  • Romantic Novels
  • Science Fiction
  • Self Help

RELATED PRODUCTS

  • How to Cook for Beginners: An Easy Cookbook for Learning the Basics £10.67
  • 5 Ingredients - Quick & Easy Food: Jamie’s most straightforward book £9.99
  • GLASS DOLLS an addictive crime thriller with a fiendish twist (Detective Dove Milson Book 1) £1.99
  • Women Don't Owe You Pretty: The debut book from Florence Given £10.65
  • The Black Cloud (Penguin Modern Classics) £7.99

PRODUCT CATEGORIES

  • Best Selling Books
  • Erotic
  • Science Fiction Books
  • Cooking
  • Business and Management
  • Education
  • Computing and IT
  • Religion & Spirituality
  • Teens & Young Adults
  • Self Help
  • Mysteries, Thrillers & Suspense
  • Romance Books
Literary Reviews

Follow us on social media:

Recent News

  • In an Astounding New Book, a Neuroscientist Reveals the Profound Benefits Art Has on Our Health
  • Is it a farce, a political thriller or a romantic trage…
  • Ebonie P. Fields’ new book Zoey and the Magical Hummingbirds receives a warm literary welcome

Category

  • Book Writing
  • Business and Management
  • Computing and IT
  • Cooking Books
  • Education
  • Erotic
  • Kindle Publishing
  • Literary Agents
  • Literary Devices
  • Literary Review
  • Literary Themes
  • Literature
  • Mysteries, Thrillers & Suspense
  • New Books
  • Religion & Spirituality
  • Romantic Novels
  • Science Fiction
  • Self Help

Recent News

In an Astounding New Book, a Neuroscientist Reveals the Profound Benefits Art Has on Our Health

In an Astounding New Book, a Neuroscientist Reveals the Profound Benefits Art Has on Our Health

March 2, 2021
Is it a farce, a political thriller or a romantic trage…

Is it a farce, a political thriller or a romantic trage…

March 2, 2021
  • Home
  • OUR BOOK SHOP
  • Literary Review
  • Literature
  • Book Writing
  • Kindle Publishing
  • Romantic
  • Science Fiction
  • Cooking
  • MORE

© 2020 literaryreviews

No Result
View All Result
  • Home
  • OUR BOOK SHOP
    • Erotic Novels
    • BEST SELLING BOOKS
    • Science Fiction Books
    • Business and Management
    • Computing and IT
    • Cooking
    • Education
    • Religion & Spirituality
    • Self Help
    • Teens & Young Adults
  • Literary Review
  • Literature
  • Book Writing
  • Kindle Publishing
  • Romantic
  • Science Fiction
  • Cooking
  • MORE
    • Erotic
    • Mysteries, Thrillers
    • Literary Themes
    • Business and Management
    • Literary Agents
    • Literary Devices
    • New Books
    • Self Help
    • Teens & Young Adults Novels
    • Computing and IT
    • Education
    • Religion & Spirituality Novels

© 2020 literaryreviews

Login to your account below

Forgotten Password?

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In